Direct Answer
Acetyl Tetrapeptide-5 (trade name Eyeseryl, by Lipotec/Lubrizol) is a synthetic peptide marketed for under-eye puffiness and bags. Its official EU CosIng function is simply "Humectant." What we don't know: we could not find any independent efficacy data, and the manufacturer's own efficacy figures were not accessible on a public source we could verify.
Summary Table
Evidence Level
Low
AI Summary
Acetyl Tetrapeptide-5 (Eyeseryl; Lipotec/Lubrizol) is a synthetic acetylated tetrapeptide marketed for the appearance of under-eye bags and puffiness, with a manufacturer-described mechanism of reduced vascular permeability and anti-glycation. Its official EU CosIng function (Ref No. 54142) is "Humectant." Independent evidence is essentially absent: no independent efficacy study was found, and the manufacturer's efficacy figures were not accessible on a verifiable public source, so no figures are reported. It should be read as a supplier-marketed cosmetic peptide with very low independent evidence.
Key Information
Classification
Key Takeaways
- What we don't know: we found no independent efficacy data, and could not verify the manufacturer's own study figures
- Acetyl Tetrapeptide-5 (Eyeseryl) is marketed for under-eye puffiness; its official CosIng function is "Humectant"
- Evidence beyond identity and the official function is manufacturer marketing only
Scientific Overview
In Plain English
Acetyl Tetrapeptide-5, sold as Eyeseryl, is a lab-made peptide put in eye creams and marketed to reduce puffiness and under-eye bags. Officially (EU CosIng) it is classed as a humectant (a moisture-holding ingredient). We could not find independent studies that it reduces eye bags, and we could not open the manufacturer's own study to check its numbers.
Scientific Details
Acetyl Tetrapeptide-5 is a synthetic acetylated tetrapeptide. The manufacturer (Lipotec/Lubrizol, trade name Eyeseryl) markets it for periorbital puffiness and bags, attributing effects to reduced vascular permeability and inhibition of protein glycation. The EU CosIng database (Ref No. 54142) lists its official cosmetic function as "Humectant." No independent controlled efficacy study was found, and manufacturer efficacy data could not be retrieved from a verifiable public source.
How It Works
The manufacturer describes Acetyl Tetrapeptide-5 as reducing vascular permeability and inhibiting glycation to limit fluid accumulation around the eyes. This is the manufacturer's proposed mechanism; it is not confirmed by independent studies cited here, and its official CosIng function is listed only as "Humectant."
Mechanism of Action
Manufacturer-proposed reduction of vascular permeability / anti-glycation
limited
Lipotec/Lubrizol describes the peptide as reducing vascular permeability and inhibiting glycation to reduce periorbital fluid accumulation. Manufacturer-described; not independently confirmed in cited sources.
Evidence Level
Human Evidence
No independent controlled human efficacy study was found. The manufacturer reports an in-house study, but it was not accessible on a public source we could verify, so no figures are reported.
Limitations
Beyond chemical identity and the official CosIng function ("Humectant"), evidence rests entirely on manufacturer (supplier) marketing that we could not independently verify.
Why This Grade
Graded low (toward the bottom of the scale): the only verifiable facts are chemical identity (PubChem) and the official EU CosIng function ("Humectant," Ref No. 54142). The anti-puffiness positioning is manufacturer (Lipotec/Lubrizol) marketing; no independent efficacy study was found, and the manufacturer's own efficacy figures were not retrievable from a verifiable public source and are excluded.
Frequently Asked Questions
What is Acetyl Tetrapeptide-5 (Eyeseryl)?
Acetyl Tetrapeptide-5, trade name Eyeseryl (Lipotec/Lubrizol), is a synthetic peptide used in eye products and marketed for under-eye puffiness and bags. Its official EU CosIng function is 'Humectant.'
Does Acetyl Tetrapeptide-5 reduce eye bags?
We could not find independent evidence that it does. The anti-puffiness claim is the manufacturer's, and the manufacturer's own study figures were not accessible on a public source we could verify. Officially, CosIng classifies it as a humectant.
What is Acetyl Tetrapeptide-5's official function?
In the EU CosIng database (Ref No. 54142), its official cosmetic function is listed as 'Humectant' — a moisture-retaining ingredient. The under-eye-bag positioning is manufacturer marketing, not the official function.
References
- Acetyl Tetrapeptide-5 — EU CosIng (Cosmetic Ingredient Database), Ref No. 54142. Official function: Humectant. (Official EU regulatory ingredient database entry; cited only for the ingredient's official cosmetic function (Humectant), not for efficacy.)Official EU CosIng function listing (Humectant) and INCI confirmation (Ref No. 54142).ReviewView source →
- Eyeseryl (Acetyl Tetrapeptide-5) — manufacturer product information (Lipotec/Lubrizol). (Manufacturer product listing (Lipotec/Lubrizol). Supplier marketing, not an independent study. The datasheet was not publicly retrievable at the time of writing (HTTP 403), so no efficacy figures are reported from it.)Manufacturer identity and marketed positioning (under-eye puffiness) only — no efficacy figures.Supplier DataView source →
Alternative Names
- Eyeseryl
- Acetyl Tetrapeptide-5
Risks & Safety
- Not an approved medicine; a cosmetic ingredient with the usual patch-test considerations
- Independent efficacy evidence is absent; anti-puffiness claims are manufacturer-based
- Independent safety data specific to this peptide are limited
Claim Boundaries
ION BLUE is an educational research aggregator. This content summarizes published scientific literature. It is not medically reviewed, is not medical advice, and is not a recommendation to use any substance. Consult a licensed healthcare provider. This entry does not assert that Acetyl Tetrapeptide-5 reduces under-eye bags or puffiness in people; such claims are the manufacturer's and are not independently verified. Its official CosIng function is "Humectant." Manufacturer efficacy figures are excluded because they could not be retrieved from a verifiable public source.
This page summarizes published research and is for informational purposes only; it is not medical advice.