Direct Answer
Matrixyl Synthe'6 (INCI palmitoyl tripeptide-38) is a lipidated tripeptide cosmetic ingredient. Cited human evidence comes from multi-ingredient serums that include palmitoyl tripeptide-38 among other actives, several with commercial or manufacturer affiliation, so effects cannot be attributed to this peptide alone.
Summary Table
Evidence Level
High
Key Information
Classification
Key Takeaways
- Matrixyl Synthe'6 is the cosmetic peptide palmitoyl tripeptide-38
- Cited human evidence is from multi-ingredient serums (several manufacturer-affiliated)
- Effects cannot be attributed to this peptide alone
Scientific Overview
In Plain English
Matrixyl Synthe'6, the cosmetic ingredient palmitoyl tripeptide-38, is a peptide used in anti-aging skincare. The human studies that reported smoother-looking skin tested multi-ingredient serums (with vitamins or other actives), several run by or for the product makers, so the benefit cannot be credited to this one peptide.
Scientific Details
Palmitoyl tripeptide-38 (Matrixyl Synthe'6) is a palmitoylated tripeptide. Open-label human studies of multi-ingredient serums that included palmitoyl tripeptide-38 (for example with vitamins C and E, or with apple stem cell extract, creatine, and urea) reported improvements in the appearance of fine lines, roughness, and skin tone. Because these were multi-ingredient formulas, and several have commercial or manufacturer affiliations, effects cannot be attributed to palmitoyl tripeptide-38 alone.
How It Works
Palmitoyl tripeptide-38 is described as a matrix-repair tripeptide; cited human evidence evaluated it within multi-ingredient serums rather than in isolation, so its individual contribution was not isolated.
Mechanism of Action
Matrix-repair signaling (formulation-level)
human
Cited studies evaluated multi-ingredient serums containing palmitoyl tripeptide-38; the individual peptide effect was not isolated.
Evidence Level
Human Evidence
Open-label human studies of multi-ingredient serums containing palmitoyl tripeptide-38 reported improvements in the appearance of fine lines, roughness, and skin tone.
Limitations
Cited evidence is from multi-ingredient formulas, several with commercial or manufacturer affiliation; effects cannot be attributed to palmitoyl tripeptide-38 alone, and open-label designs limit interpretation.
References
- A serum containing vitamins C & E and a matrix-repair tripeptide reduces facial signs of aging as evidenced by Primos analysis and frequently repeated auto-perception. Journal of Cosmetic Dermatology.Human Studydoi:10.1111/jocd.13770 →
- Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro-collagen lipopeptide, creatine, and urea on skin aging signs. Journal of Cosmetic Dermatology.Human Studydoi:10.1111/jocd.12173 →
Alternative Names
- Matrixyl Synthe'6
- Palmitoyl tripeptide-38
- Pal-tripeptide-38
Claim Boundaries
ION BLUE is an educational research aggregator. This content summarizes published scientific literature. It is not medically reviewed, is not medical advice, and is not a recommendation to use any substance. Several peptides discussed are research chemicals not approved for human use. Consult a licensed healthcare provider. Cited evidence is from multi-ingredient, often manufacturer-affiliated formulas; this entry does not attribute effects to this peptide alone and is not a recommendation to use it.
This page summarizes published research and is for informational purposes only; it is not medical advice.